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说明： Potent GABAA antagonist
化学名： 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-1H-pyrazol-4-yl)piperidine trifluoroacetate
纯度： ≥98% (HPLC)
生物活性 for PHP 501 trifluoroacetate
PHP 501 trifluoroacetate is a potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.
技术数据 for PHP 501 trifluoroacetate
| 分子量 | 433.42 |
| 公式 | C20H21N3O.CF3CO2H |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1781880-44-1 |
| PubChem ID | 90488945 |
| InChI Key | SULXXKLCQRXMHP-UHFFFAOYSA-N |
| Smiles | ON1N=CC(C3CCNCC3)=C1C2=CC=CC(C4=CC=CC=C4)=C2.FC(F)(C(O)=O)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PHP 501 trifluoroacetate
参考文献 for PHP 501 trifluoroacetate
参考文献是支持产品生物活性的出版物。
Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417 PMID: 20355712
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关键词: PHP 501 trifluoroacetate, PHP 501 trifluoroacetate supplier, GABAA, receptors, antagonists, potent, PHP501, Receptors, 4466, Tocris Bioscience
1 篇 PHP 501 trifluoroacetate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PHP 501 trifluoroacetate 的部分引用包括：
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241
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