PHPS1 sodium salt

Cat. No. 6771 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Shp2 (PTPN11) inhibitor

化学名： 4-[2-[1,5-Dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]benzenesulfonic acid sodium salt

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PHPS1 sodium salt

PHPS1 sodium salt is a Shp2 (PTPN11) inhibitor (IC₅₀ = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.

技术数据 for PHPS1 sodium salt

分子量	487.42
公式	C₂₁H₁₄N₅O₆SNa
储存	Store at -20°C
纯度	≥98% (HPLC)
PubChem ID	136664438
InChI Key	MNHVHZFYTKWRFD-UHFFFAOYSA-M
Smiles	O=S(C1=CC=C(C=C1)N/N=C2C(N(C3=CC=CC=C3)N=C\2C4=CC=C([N+]([O-])=O)C=C4)=O)(O[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PHPS1 sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.75	20

制备储备液 for PHPS1 sodium salt

以下数据基于产品分子量 487.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	10.26 mL	51.29 mL	102.58 mL
1 mM	2.05 mL	10.26 mL	20.52 mL
2 mM	1.03 mL	5.13 mL	10.26 mL
10 mM	0.21 mL	1.03 mL	2.05 mL

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产品说明书 for PHPS1 sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PHPS1 sodium salt

参考文献是支持产品生物活性的出版物。

Hellmuth et al (2008) Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc.Natl.Acad.Sci.U.S.A 105 7275 PMID: 18480264

Ahrendsen et al (2018) The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination. J.Neurosci. 38 787 PMID: 29217681

Zehender et al (2018) The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat.Commun. 9 3259 PMID: 30108215

If you know of a relevant reference for PHPS1 sodium salt, please let us know.

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关键词: PHPS1 sodium salt, PHPS1 sodium salt supplier, shp2, ptpn11, inhibitors, inhibits, myelination, fibrosis, Protein, Tyrosine, Phosphatases, 6771, Tocris Bioscience

1 篇 PHPS1 sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PHPS1 sodium salt 的部分引用包括：

Dinko et al (2023) Human Oral Mucosa Stem Cells Increase Survival of Neurons Affected by In Vitro Anoxia and Improve Recovery of Mice Affected by Stroke Through Time-limited Secretion of miR-514A-3p. Cell Mol Neurobiol 43 1975-1988 PMID: 36083390

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