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Submit ReviewPicrotoxin
说明： GABAA antagonist
纯度： ≥97% (HPLC)
生物活性 for Picrotoxin
Picrotoxin is a GABAA receptor antagonist; potent CNS stimulant.
技术数据 for Picrotoxin
| 分子量 | 602.59 |
| 公式 | C30H34O13 |
| 储存 | Store at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 124-87-8 |
| PubChem ID | 6473767 |
| InChI Key | VJKUPQSHOVKBCO-ZYMHLGHZSA-N |
| Smiles | [H][C@@]12OC([C@@](C1(C(C)=C)[H])([C@@]3(C[C@H]4O[C@]45C(O[C@]2([C@]35C)[H])=O)O)[H])=O.[H][C@@]67OC([C@@](C6(C(C)(O)C)[H])([C@@]8(C[C@H]9O[C@]9%10C(O[C@]7([C@]8%10C)[H])=O)O)[H])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Picrotoxin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 30.13 | 50 温和加热 | |
| DMSO | 12.05 | 20 |
制备储备液 for Picrotoxin
以下数据基于产品分子量 602.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.32 mL | 16.6 mL | 33.19 mL |
| 2.5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 25 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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产品说明书 for Picrotoxin
参考文献 for Picrotoxin
参考文献是支持产品生物活性的出版物。
Dillon et al (1995) Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned α1β2γ2 GABAA receptor subtype. Br.J.Pharmacol. 115 539 PMID: 7582470
Ette et al (1999) Picrotoxin blockade of inverterbrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore. J.Neurochem. 72 318 PMID: 9886084
Newland and Cull-Candy (1992) On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. J.Physiol. 447 191 PMID: 1317428
Merck Index 12 7570
If you know of a relevant reference for Picrotoxin, please let us know.
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关键词: Picrotoxin, Picrotoxin supplier, GABAA, receptor, antagonists, Receptors, picrotin, 1128, Tocris Bioscience
126 篇 Picrotoxin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Picrotoxin 的部分引用包括：
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Works as GABA-A receptor antagonist..
By
Anonymous on 06/01/2020
分析类型： Ex Vivo
种属： Mouse
Picrotoxin stock was prepared in DMSO and diluted with ACSF to 25 micromolar concentration. Bath application of Picrotoxin blocked evoked inhibitory postsynaptic currents in an ex-vivo slice preparation.
Picrotoxin blocks single-channel openings of GABA-A receptor.
By
Anonymous on 07/21/2019
分析类型： In Vitro
种属： Rat
细胞系/组织： Hippocampus
20 microM Picrotoxin concentration was used to block GABA-A receptor openings in nucleated cell membrane patches. Full block was achieved in ~30 seconds after application. Picture: GABA-A receptor openings under control conditions (top three traces) and after application of Picrotoxin (bottom trace).
silence GABA activity.
By
Karthik krishnamurthy on 10/26/2018
分析类型： In Vitro
种属： Rat
细胞系/组织： cortical neurons
Used to block GABA activity in 16 day old cortical neurons. Effective at 10 micromolar concentration. Incubated for 30 minutes before measuring bursts.
GABA blocker.
By
Anonymous on 10/02/2018
分析类型： Ex Vivo
种属： Rat
Used for electrophysiology to block GABA currents. Works as expected
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