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Submit ReviewPindolol
Discontinued Product
0994 has been discontinued.
View all Adrenergic β<sub>3</sub> Receptors products.
说明： β3 partial agonist; also a 5-HT1A and 5-HT1B antagonist
化学名： 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
纯度： ≥99% (HPLC)
生物活性 for Pindolol
5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors.
S-enantiomer also available.
技术数据 for Pindolol
| 分子量 | 248.32 |
| 公式 | C14H20N2O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 13523-86-9 |
| PubChem ID | 4828 |
| InChI Key | JZQKKSLKJUAGIC-UHFFFAOYSA-N |
| Smiles | CC(C)NCC(O)COC1=C2C=CNC2=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Pindolol
参考文献 for Pindolol
参考文献是支持产品生物活性的出版物。
Blin et al (1993) Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor. Mol.Pharmacol. 44 1094 PMID: 7903415
Clifford et al (1998) Electrophysiological and neurochemical evidence that pin. has agonist properties at the 5-HT1A autoreceptor in vivo. Br.J.Pharmacol. 124 206 PMID: 9630361
Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449 PMID: 9504386
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Merck Index 12 7597
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关键词: Pindolol, Pindolol supplier, 5-HT1A/1B, antagonists, β3-adrenoceptor, β3-adrenergic, b3-adrenoceptor, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B, Adrenergic, Beta-3, 0994, Tocris Bioscience
5 篇 Pindolol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pindolol 的部分引用包括：
Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344 PMID: 21183739
Luo (2017) β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Scientific Reports 7 39905 PMID: 28051147
Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Front Microbiol 355 183 PMID: 26306764
Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319
Marinelli et al (2004) Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. J Neurophysiol 92 3532 PMID: 15254076
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.