Pirenzepine dihydrochloride

Name: Pirenzepine dihydrochloride
Brand: Tocris Bioscience
SKU: 1071

Cat. No. 1071 16 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1071 has been discontinued.

View all M<sub>1</sub> Receptors products.

说明： Selective M₁ antagonist

化学名： 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (16)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Pirenzepine dihydrochloride

Pirenzepine dihydrochloride is a M₁ muscarinic receptor selective antagonist. Inverse agonist activity reported.

技术数据 for Pirenzepine dihydrochloride

分子量	424.33
公式	C₁₉H₂₁N₅O₂.2HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	29868-97-1
PubChem ID	71405
InChI Key	FFNMBRCFFADNAO-UHFFFAOYSA-N
Smiles	O=C1C3=C(C=CC=C3)N(C(CN4CCN(CC4)C)=O)C2=C(C=CC=N2)N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Pirenzepine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Pirenzepine dihydrochloride

参考文献是支持产品生物活性的出版物。

Daeffler et al (1999) Inverse agonist activity of pirenzepine at M₂ muscarinic acetylcholine receptors. Br.J.Pharmacol. 126 1246 PMID: 10205015

Doods et al (1994) Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur.J.Pharmacol. 253 275 PMID: 8200421

Eglen et al (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 48 531 PMID: 8981565

Hammer et al (1980) Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature 283 90 PMID: 7350532

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关键词: Pirenzepine dihydrochloride, Pirenzepine dihydrochloride supplier, Selective, M1, muscarinic, antagonists, Receptors, Acetylcholine, ACh, 1071, Tocris Bioscience

16 篇 Pirenzepine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pirenzepine dihydrochloride 的部分引用包括：

Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768

Nadal et al (2017) Presynaptic Muscarinic Acetylcholine Receptors and TrkB Receptor Cooperate in the Elimination of Redundant Motor Nerve Terminals during Development. Front Aging Neurosci 9 24 PMID: 28228723

Pacini et al (2014) M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther 15 1489 PMID: 25482946

Mans et al (2014) An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol 112 2388 PMID: 25143547

Ross et al (2019) Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning. Front Behav Neurosci 13 164 PMID: 31379534

Thomson et al (2017) Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron 95 550 PMID: 28772121

Martin et al (2015) Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Proc Natl Acad Sci U S A 9 457 PMID: 26648844

Hulme et al (2012) Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus. J Neurosci 32 6785 PMID: 22593048

Garcia et al (2010) The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals. J Neurosci 30 16514 PMID: 21147991

Tian et al (2016) STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit Scientific Reports 6 36684 PMID: 27857196

Buchanan et al (2010) Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron 68 948 PMID: 21145007

Pediani et al (2016) Dynamic regulation of quaternary organization of the M₁ muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem. 291 13132 PMID: 27080256

Ahmed (2016) Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models. Physiological Reports 4 e13069 PMID: 28039410

Tozzi et al (2012) A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS One 7 e38312 PMID: 22715379

Zucca et al (2018) Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo. Elife 7 PMID: 29578407

Nadal et al (2016) Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction. Front Cell Neurosci 9 67 PMID: 27339059