PKUMDL WQ 2101

Cat. No. 6580 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

化学名： 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PKUMDL WQ 2101

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC₅₀ = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC₅₀ values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.

技术数据 for PKUMDL WQ 2101

分子量	317.25
公式	C₁₄H₁₁N₃O₆
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	304481-72-9
PubChem ID	6741780
InChI Key	RABUUVVWWJCYEN-UHFFFAOYSA-N
Smiles	OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PKUMDL WQ 2101

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	31.73	100

制备储备液 for PKUMDL WQ 2101

以下数据基于产品分子量 317.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.76 mL	31.52 mL
5 mM	0.63 mL	3.15 mL	6.3 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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产品说明书 for PKUMDL WQ 2101

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PKUMDL WQ 2101

参考文献是支持产品生物活性的出版物。

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046

If you know of a relevant reference for PKUMDL WQ 2101, please let us know.

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关键词: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience

1 篇 PKUMDL WQ 2101 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PKUMDL WQ 2101 的部分引用包括：

John M et al (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun 13 2698 PMID: 35577785

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