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PKUMDL WQ 2201

Cat. No. 6581 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
化学名： 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PKUMDL WQ 2201

PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

技术数据 for PKUMDL WQ 2201

分子量 351.81
公式 C15H14ClN3O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 592474-91-4
PubChem ID 5453153
InChI Key XPACBFAEZIPDRT-LSCVHKIXSA-N
Smiles CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PKUMDL WQ 2201

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.18 100

制备储备液 for PKUMDL WQ 2201

以下数据基于产品分子量 351.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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参考文献 for PKUMDL WQ 2201

参考文献是支持产品生物活性的出版物。

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046

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关键词: PKUMDL WQ 2201, PKUMDL WQ 2201 supplier, PKUMDLWQ2201, PKUMDL-WQ-2201, PHGDH, 3-Phosphoglycerate, dehydrogenase, inhibitors, inhibits, negative, allosteric, modulators, anti-tumor, antitumor, NAM, Other, Dehydrogenases, 6581, Tocris Bioscience

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