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Submit ReviewPKUMDL WQ 2201
说明： Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
化学名： 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for PKUMDL WQ 2201
PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.
技术数据 for PKUMDL WQ 2201
| 分子量 | 351.81 |
| 公式 | C15H14ClN3O3S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 592474-91-4 |
| PubChem ID | 5453153 |
| InChI Key | XPACBFAEZIPDRT-LSCVHKIXSA-N |
| Smiles | CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PKUMDL WQ 2201
参考文献 for PKUMDL WQ 2201
参考文献是支持产品生物活性的出版物。
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046
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关键词: PKUMDL WQ 2201, PKUMDL WQ 2201 supplier, PKUMDLWQ2201, PKUMDL-WQ-2201, PHGDH, 3-Phosphoglycerate, dehydrogenase, inhibitors, inhibits, negative, allosteric, modulators, anti-tumor, antitumor, NAM, Other, Dehydrogenases, 6581, Tocris Bioscience
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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