(+)-Anabasine hydrochloride

Cat. No. 1971 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity nAChR partial agonist

化学名： (S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride

纯度： ≥99% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (+)-Anabasine hydrochloride

(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (K_i values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca²⁺-dependent catecholamine release from rat adrenomedullary cells in vitro.

技术数据 for (+)-Anabasine hydrochloride

分子量	198.69
公式	C₁₀H₁₄N₂.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	53912-89-3
PubChem ID	3041330
InChI Key	VTMZQNZVYCJLGG-PPHPATTJSA-N
Smiles	[C@]1([C@H]2NCCCC2)=CC=CN=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (+)-Anabasine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	19.87	100

制备储备液 for (+)-Anabasine hydrochloride

以下数据基于产品分子量 198.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	5.03 mL	25.16 mL	50.33 mL
5 mM	1.01 mL	5.03 mL	10.07 mL
10 mM	0.5 mL	2.52 mL	5.03 mL
50 mM	0.1 mL	0.5 mL	1.01 mL

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产品说明书 for (+)-Anabasine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (+)-Anabasine hydrochloride

参考文献是支持产品生物活性的出版物。

Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967

Parker et al (1998) Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 54 1132 PMID: 9855644

Lu et al (1999) Desensitization of nicotinic agonist-induced [³H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 291 1127 PMID: 10565833

Hong et al (2007) Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 50 351 PMID: 18186309

If you know of a relevant reference for (+)-Anabasine hydrochloride, please let us know.

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关键词: (+)-Anabasine hydrochloride, (+)-Anabasine hydrochloride supplier, Neuronal, nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1971, Tocris Bioscience

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