(+)-Anabasine hydrochloride

Name: (+)-Anabasine hydrochloride
Brand: Tocris Bioscience
SKU: 1971

Cat. No. 1971 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1971 has been discontinued.

View all Nicotinic Receptors (Non-selective) products.

说明： High affinity nAChR partial agonist

化学名： (S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for (+)-Anabasine hydrochloride

(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (K_i values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca²⁺-dependent catecholamine release from rat adrenomedullary cells in vitro.

技术数据 for (+)-Anabasine hydrochloride

分子量	198.69
公式	C₁₀H₁₄N₂.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	53912-89-3
PubChem ID	3041330
InChI Key	VTMZQNZVYCJLGG-PPHPATTJSA-N
Smiles	[C@]1([C@H]2NCCCC2)=CC=CN=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (+)-Anabasine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (+)-Anabasine hydrochloride

参考文献是支持产品生物活性的出版物。

Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967

Parker et al (1998) Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 54 1132 PMID: 9855644

Lu et al (1999) Desensitization of nicotinic agonist-induced [³H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 291 1127 PMID: 10565833

Hong et al (2007) Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 50 351 PMID: 18186309

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关键词: (+)-Anabasine hydrochloride, (+)-Anabasine hydrochloride supplier, Neuronal, nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1971, Tocris Bioscience

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