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Submit Review(+)-Tubocurarine chloride
说明： nAChR antagonist
化学名： 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
纯度： ≥98% (HPLC)
生物活性 for (+)-Tubocurarine chloride
(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.
技术数据 for (+)-Tubocurarine chloride
| 分子量 | 681.65 |
| 公式 | C37H41ClN2O6.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 57-94-3 |
| PubChem ID | 64645 |
| InChI Key | GXFZCDMWGMFGFL-KKXMJGKMSA-N |
| Smiles | OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (+)-Tubocurarine chloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 17.04 | 25 |
制备储备液 for (+)-Tubocurarine chloride
以下数据基于产品分子量 681.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 5.87 mL | 29.34 mL | 58.68 mL |
| 1.25 mM | 1.17 mL | 5.87 mL | 11.74 mL |
| 2.5 mM | 0.59 mL | 2.93 mL | 5.87 mL |
| 12.5 mM | 0.12 mL | 0.59 mL | 1.17 mL |
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产品说明书 for (+)-Tubocurarine chloride
参考文献 for (+)-Tubocurarine chloride
参考文献是支持产品生物活性的出版物。
Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785
Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107
Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293
If you know of a relevant reference for (+)-Tubocurarine chloride, please let us know.
关键词: (+)-Tubocurarine chloride, (+)-Tubocurarine chloride supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, (Non-selective), 2820, Tocris Bioscience
10 篇 (+)-Tubocurarine chloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (+)-Tubocurarine chloride 的部分引用包括：
Truszkowski et al (2017) A cellular mechanism for inverse effectiveness in multisensory integration. Elife 6 PMID: 28315524
Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816
Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652
Nagel et al (2015) Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics. Nat Neurosci 18 56 PMID: 25485755
Lamy et al (2010) Allosteric block of KCa2 channels by apamin. J Neurophysiol 285 27067 PMID: 20562108
Roemmich et al (2018) Ex vivo Whole-cell Recordings in Adult Drosophila Brain. Bio Protoc 8 PMID: 30148187
Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Biol Chem 31 2937 PMID: 22531784
Corns et al (2018) Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nat Commun 9 4015 PMID: 30275467
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. BMC Syst Biol 9 30 PMID: 25717295
Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Front Behav Neurosci 110 103 PMID: 23576702
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Neuromuscular blocking drugs.
By
Anonymous on 02/16/2018
分析类型： In Vivo
种属： Other
We use 2 mg of tubocurarine in a demonstration experiment to review its properties as a neuromuscular blocking drug
To emphasize its action mechanism is useful to compare it with 2 mg of Succinylcholine in a chicken model
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.