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Submit ReviewPMX 464
说明： Putative inhibitor of the Trx-TrxR system; antiproliferative
化学名： 4-(2-Benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
纯度： ≥98% (HPLC)
生物活性 for PMX 464
PMX 464 is a putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.
技术数据 for PMX 464
| 分子量 | 243.28 |
| 公式 | C13H9NO2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 485842-97-5 |
| PubChem ID | 482697 |
| InChI Key | SDYBYKXWYDVVKP-UHFFFAOYSA-N |
| Smiles | O=C(C=C3)C=CC3(O)C2=NC1=CC=CC=C1S2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PMX 464
参考文献 for PMX 464
参考文献是支持产品生物活性的出版物。
Mukherjee et al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167 PMID: 17572693
Callister et al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661 PMID: 18587424
Mukherjee et al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350 PMID: 15655539
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关键词: PMX 464, PMX 464 supplier, PMX464, PMX_464, antiproliferative, thioredoxin, reductase, TrxR, Trx1, inhibitors, inhibits, cell, proliferation, Thioredoxin, Reductases, 4996, Tocris Bioscience
1 篇 PMX 464 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PMX 464 的部分引用包括：
Schroeder (2017) Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death Sci Rep 7 43168 PMID: 28233787
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