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Submit ReviewPoly(I:C)
说明： TLR3 agonist
化学名： Polyinosinic-polycytidylic acid sodium salt
生物活性 for Poly(I:C)
Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat. No. 6142). Transfection into NIT-1 β cells induces β-cell apoptosis.
To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.
技术数据 for Poly(I:C)
| 公式 | (C10H13N4O8P)x.(C9H14N3O8P)x |
| 储存 | Store at -20°C |
| CAS Number | 42424-50-0 |
| PubChem ID | 32744 |
| InChI Key | ACEVNMQDUCOKHT-ZLOOHWKQSA-N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Poly(I:C)
| 溶解性 | Soluble to 3 mg/ml in water |
产品说明书 for Poly(I:C)
参考文献 for Poly(I:C)
参考文献是支持产品生物活性的出版物。
Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048
Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480
West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932
Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554
Biermann et al (2019) Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. Stem Cells 37 910 PMID: 31087611
Waele et al (2021) A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy. J.Exp.Clin.Cancer Res. 40 213 PMID: 34172082
If you know of a relevant reference for Poly(I:C), please let us know.
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关键词: Poly(I:C), Poly(I:C) supplier, Poly(I:C), immunostimulant, toll-like, receptor, TLR, TLR3, agonist, inosinic, acid, cytidylic, double-stranded, RNA, dsRNA, synthetic, maternal, immune, activation, MIA, cardiomyocyte, differentiation, maturation, RIG-I, MDA-5, IFN, Notch, signaling, Toll-like, Receptors, Cardiomyocyte, Stem, Cells, 4287, Tocris Bioscience
20 篇 Poly(I:C) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Poly(I:C) 的部分引用包括：
Tachibana et al (2022) Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks. Comp.Biochem.Physiol.A Mol.Integr.Physiol. 269 111211 PMID: 35417747
Mingjun et al (2023) A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3. iScience 26 105935 PMID: 36685041
Alyssa H et al (2023) Weight cycling induces innate immune memory in adipose tissue macrophages. Front Immunol 13 984859 PMID: 36713396
Anne et al (2023) Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe. Cell Genom 3 100248 PMID: 36819665
Alexa et al (2023) Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells. Heliyon 9 e15202 PMID: 37123974
Hideaki et al (2020) TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis. Front Immunol 11 98 PMID: 32117252
Yu et al (2018) Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol Cell 72 999 PMID: 30449722
Shahram et al (2021) EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8+ T Cells. Front Immunol 12 770080 PMID: 34925340
Ivan et al (2021) PERK Is Critical for Alphavirus Nonstructural Protein Translation. Viruses 13 PMID: 34065980
Yi et al (2021) ADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in Macrophages. Arterioscler Thromb Vasc Biol 41 1854-1873 PMID: 33882688
Veronica Elizabeth et al (2021) Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription. J Immunol 207 1437-1447 PMID: 34400522
Yue et al (2018) PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2. Neuron 100 183-200.e8 PMID: 30269986
Masayuki et al (2016) Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine. Front Cell Infect Microbiol 5 105 PMID: 26793623
Nicolas et al (2019) IL-17c is involved in olfactory mucosa responses to Poly(I:C) mimicking virus presence. Brain Behav Immun 79 274-283 PMID: 30776474
Tröscher et al (2019) Microglial nodules provide the environment for pathogenic T cells in human encephalitis. Acta Neuropathol 137 619 PMID: 30663001
Scott W et al (2022) TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell Stem Cell 29 298-314.e9 PMID: 35045331
Xuefei et al (2022) Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions. BMC Biol 20 14 PMID: 35027054
Takashi et al (2022) Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release. Front Immunol 13 921728 PMID: 35941890
Sandra et al (2022) Assessing human iPSC-derived microglia identity and function by immunostaining, phagocytosis, calcium activity, and inflammation assay. STAR Protoc 3 101866 PMID: 36595902
Johann et al (2022) Pro-inflammatory activation changes intracellular transport of bevacizumab in the retinal pigment epithelium in vitro. Graefes Arch Clin Exp Ophthalmol 260 857-872 PMID: 34643794
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Poly IC.
By
shubham dubey on 12/22/2021
分析类型： In Vitro
种属： Human
细胞系/组织： 16HBE
To activate TLR3
Pathways for Poly(I:C)
