Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPPNDS
说明： Potent and selective P2X1 antagonist
化学名： Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt
生物活性 for PPNDS
PPNDS is a potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.
技术数据 for PPNDS
| 分子量 | 694.36 |
| 公式 | C18H11N4Na4O14PS2 |
| 储存 | Desiccate at -20°C |
| CAS Number | 1021868-77-8 |
| PubChem ID | 2750 |
| InChI Key | XHWIRFKQZFSILU-MKMLRUMESA-J |
| Smiles | CC1=C(O)C(C=O)=C(COP(O[Na])(O[Na])=O)C(/N=N/C2=CC3=C(C=C(C=C3C(S(=O)(O[Na])=O)=C2)[N+]([O-])=O)S(=O)(O[Na])=O)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PPNDS
参考文献 for PPNDS
参考文献是支持产品生物活性的出版物。
Lambrecht et al (2000) The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur.J.Pharmacol. 387 R19 PMID: 10650184
按标靶查看相关产品
按产品操作查看相关产品
关键词: PPNDS, PPNDS supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, P2X, 1309, Tocris Bioscience
1 篇 PPNDS 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PPNDS 的部分引用包括：
Madoux et al (2014) Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers 102 396 PMID: 25048711
PPNDS 的评论
目前没有该产品的评论。 Be the first to review PPNDS and earn rewards!
Have you used PPNDS?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.