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Submit ReviewPPQ 102
说明： Potent, voltage-independent CFTR chloride channel inhibitor
化学名： 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
纯度： ≥98% (HPLC)
生物活性 for PPQ 102
PPQ 102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.
技术数据 for PPQ 102
| 分子量 | 438.48 |
| 公式 | C26H22N4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 931706-15-9 |
| PubChem ID | 16016583 |
| InChI Key | MNOOVRNGPIWJDI-UHFFFAOYSA-N |
| Smiles | O=C(N2C)C1=C(C3=CC=CC=C3)N4C(C(C6=CC=C(C)O6)NC5=C4C=CC=C5)=C1N(C)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PPQ 102
参考文献 for PPQ 102
参考文献是支持产品生物活性的出版物。
Tradtrantip et al (2009) Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 52 6447 PMID: 19785436
Martin et al (2013) CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 42 1553 PMID: 23520314
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关键词: PPQ 102, PPQ 102 supplier, PPQ102, potent, voltage, independent, CFTR, chloride, channel, inhibitors, inhibits, cystic, fibrosis, transmembrane, conductance, 4303, Tocris Bioscience
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平均评分: 5 (Based on 1 Review.)
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PPQ 102 inhibited of CFTR chloride current was studied.
By
Lutpine Rachel on 01/16/2020
种属： Human
PPQ-102 inhibited of CFTR chloride current was studied.Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state.
