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Pregabalin

Cat. No. 3775 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3775 has been discontinued.

View all Non-selective Ca<sub>v</sub> Channels products.
说明： Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels
化学名： (S)-3-(Aminomethyl)-5-methylhexanoic acid
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Pregabalin

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for Pregabalin

分子量 159.23
公式 C8H17NO2
储存 Store at RT
CAS Number 148553-50-8
PubChem ID 5486971
InChI Key AYXYPKUFHZROOJ-ZETCQYMHSA-N
Smiles CC(C)C[C@H](CN)CC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Pregabalin

参考文献是支持产品生物活性的出版物。

Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553

Kumar et al (2010) Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471

Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407

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关键词: Pregabalin, Pregabalin supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+, Non-selective, Cav, Channels, 3775, Tocris Bioscience

篇 Pregabalin 的引用文献

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Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-GAD.
By Anonymous on 12/26/2019
种属： Human

Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-glutamic acid decarboxylase (GAD), the enzyme responsible for synthesizing GABA, and hence how it may have some indirect GABAergic effects by increasing GABA levels in the brain.

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