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Submit ReviewPregnanolone
说明： Postitive allosteric modulator of GABAA receptors
化学名： (3α,5β)-3-Hydroxy-pregnan-20-one
生物活性 for Pregnanolone
Pregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
技术数据 for Pregnanolone
| 分子量 | 318.49 |
| 公式 | C21H34O2 |
| 储存 | Store at RT |
| CAS Number | 128-20-1 |
| PubChem ID | 31402 |
| InChI Key | AURFZBICLPNKBZ-YZRLXODZSA-N |
| Smiles | C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pregnanolone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.85 | 100 | |
| ethanol | 31.85 | 100 |
制备储备液 for Pregnanolone
以下数据基于产品分子量 318.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.4 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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产品说明书 for Pregnanolone
参考文献 for Pregnanolone
参考文献是支持产品生物活性的出版物。
Harrison et al (1987) Structure-activity relationships for steroid interaction with the γ-aminobutyric acidA receptor complex. J.Pharmacol.Exp.Ther. 241 346 PMID: 3033209
Morris et al (1999) Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 56 752 PMID: 10496958
If you know of a relevant reference for Pregnanolone, please let us know.
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关键词: Pregnanolone, Pregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, Receptors, 3652, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.