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Submit ReviewPregnenolone sulfate sodium salt
说明： NMDA potentiator; also GABAA inhibitor and TRPM3 activator
化学名： (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
生物活性 for Pregnenolone sulfate sodium salt
Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.
技术数据 for Pregnenolone sulfate sodium salt
| 分子量 | 418.52 |
| 公式 | C21H31NaO5S |
| 储存 | Store at +4°C |
| CAS Number | 1852-38-6 |
| PubChem ID | 23676306 |
| InChI Key | QQVJEIZJHDPTSH-UTNKIXDHSA-M |
| Smiles | O=[C@](C)[C@H]4CC[C@@]3([H])[C@]2([H])CC=C1C[C@@H](OS(=O)([O-])=O)CC[C@@](C)1[C@]([H])2CC[C@@]34C.[Na+] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pregnenolone sulfate sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 20.93 | 50 |
制备储备液 for Pregnenolone sulfate sodium salt
以下数据基于产品分子量 418.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.78 mL | 23.89 mL | 47.79 mL |
| 2.5 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 25 mM | 0.1 mL | 0.48 mL | 0.96 mL |
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产品说明书 for Pregnenolone sulfate sodium salt
参考文献 for Pregnenolone sulfate sodium salt
参考文献是支持产品生物活性的出版物。
Li et al (2007) Neuroactive steroids and human recombinant rho1 GABAC receptors. J.Pharmacol.Exp.Ther. 323 236 PMID: 17636008
Majeed et al (2010) Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br.J.Pharmacol. 161 430 PMID: 20735426
Smith et al (2014) A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol.Pharmacol. 86 390 PMID: 25057049
Seljeset et al (2018) Probing GABAA receptors with inhibitory neurosteroids. Neuropharmacology 136 23 PMID: 29447845
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关键词: Pregnenolone sulfate sodium salt, Pregnenolone sulfate sodium salt supplier, neuroactive, steroids, highly, potent, NMDA, TRPM3, memory, LTP, potentiators, activates, activators, GABA, Receptors, TRPM, GABAA, 5376, Tocris Bioscience
1 篇 Pregnenolone sulfate sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pregnenolone sulfate sodium salt 的部分引用包括：
Luoma et al (2011) Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids 76 845 PMID: 21371490
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