主页 / 药理学 / Other Pharmacology / Antivirals / Herpes Simplex Viruses / Pritelivir

Pritelivir

Cat. No. 7321 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
化学名： N-[5-(Aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)benzeneacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pritelivir

Pritelivir is a potent and selective herpes simplex virus (HSV) helicase primase inhibitor. Pritelivir inhibits viral replication in Vero cells (IC50 = 0.02 μM for HSV-1 and HSV-2). It also reduces β-amyloid and P-tau levels in Vero cells. Pritelivir is active against clinical isolates and porcine and bovine HSV strains but displays reduced activity against varicella zoster virus and cytomegalovirus in vitro. In addition, the compound exhibits antiviral activity in HSV infected mice.

技术数据 for Pritelivir

分子量 402.49
公式 C18H18N4O3S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 348086-71-5
PubChem ID 491941
InChI Key IVZKZONQVYTCKC-UHFFFAOYSA-N
Smiles O=C(N(C1=NC(=C(S1)S(=O)(=O)N)C)C)CC=2C=CC(=CC2)C3=NC=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pritelivir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.12 50 温和加热

制备储备液 for Pritelivir

以下数据基于产品分子量 402.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.97 mL 24.85 mL 49.69 mL
2.5 mM 0.99 mL 4.97 mL 9.94 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
25 mM 0.1 mL 0.5 mL 0.99 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Pritelivir

参考文献是支持产品生物活性的出版物。

Kleymann et al (2002) New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat.Med. 8 392 PMID: 11927946

Wozniak et al (2013) The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1. Antiviral Res. 99 401 PMID: 23867133

If you know of a relevant reference for Pritelivir, please let us know.

按标靶查看相关产品

关键词: Pritelivir, Pritelivir supplier, herpes, simplex, virus, HSV-1, HSV-2, helicase, primase, inhibitors, inhibits, antiviral, beta-amyloid, B-amyloid, P-tau, Herpes, Simplex, Viruses, DNA,, RNA, and, Protein, Synthesis, 7321, Tocris Bioscience

篇 Pritelivir 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Pritelivir 的引用文献。 您是否知道使用了 Tocris Pritelivir 的优秀论文？ 请告知我们.

Pritelivir 的评论

目前没有该产品的评论。 Be the first to review Pritelivir and earn rewards!

Have you used Pritelivir?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review