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说明： ABCA1 (CERP) inhibitor; also antioxidant, anti-inflammatory and hypocholesterolemic agent
化学名： 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
纯度： ≥99% (HPLC)
生物活性 for Probucol
Probucol is an ABCA1 (CERP) inhibitor. Inhibits cholesterol efflux from J774 macrophages expressing ABCA1 by up to 80%. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Antioxidant, anti-inflammatory and hypocholesterolemic agent.
技术数据 for Probucol
| 分子量 | 516.84 |
| 公式 | C31H48O2S2 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 23288-49-5 |
| PubChem ID | 4912 |
| InChI Key | FYPMFJGVHOHGLL-UHFFFAOYSA-N |
| Smiles | CC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Probucol
参考文献 for Probucol
参考文献是支持产品生物活性的出版物。
Ruixing et al (2006) Pretreatment with prob. attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 66 549 PMID: 17101546
Wu et al (2007) Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 321 477 PMID: 17293560
Favari et al (2004) Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler.Thromb.Vasc.Biol. 24 2345 PMID: 15514211
Wu et al (2004) Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation. J.Biol.Chem. 279 30168 PMID: 15140889
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关键词: Probucol, Probucol supplier, Antioxidant, anti-inflammatory, hypocholesterolemic, hypocholesterolaemic, agent, ATP-binding, cassette, ABCA1, CERP, Antioxidants, Multidrug, Transporters, 2775, Tocris Bioscience
1 篇 Probucol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Probucol 的部分引用包括：
Guo et al (2016) VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun 7 12646 PMID: 27561680
Probucol 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
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