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Submit ReviewProgesterone is an endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM).
分子量 | 314.46 |
公式 | C21H30O2 |
储存 | Store at RT |
纯度 | ≥99% (HPLC) |
CAS Number | 57-83-0 |
PubChem ID | 5994 |
InChI Key | RJKFOVLPORLFTN-LEKSSAKUSA-N |
Smiles | O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](C)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 31.45 | 100 | |
ethanol | 31.45 | 100 |
以下数据基于产品分子量 314.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.18 mL | 15.9 mL | 31.8 mL |
5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
参考文献是支持产品生物活性的出版物。
Dong et al (2004) Characterization of a new class of selective nonsteroidal progesterone receptor agonist. Steroids 69 201 PMID: 15072922
Jerry (2007) Roles of estrogen and progesterone in breast cancer prevention. Breast Cancer Res. 9 102 PMID: 17381827
If you know of a relevant reference for Progesterone, please let us know.
关键词: Progesterone, Progesterone supplier, Endogenous, progesterone, receptors, agonists, Progesterone, Receptor, 2835, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Progesterone 的部分引用包括:
Gibson et al (2016) Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes. Sci Rep 6 19970 PMID: 26817618
Gibson et al (2018) Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age. Fertil Steril 109 728 PMID: 29397924
Gibson et al (2018) SULFATION PATHWAYS: A role for steroid sulphatase in intracrine regulation of endometrial decidualisation. J Mol Endocrinol 61 M57 PMID: 29720512
White et al (2011) The serotonin transporter, gender, and 17β OE in the development of pulmonary arterial hypertension. J Neurosci 90 373 PMID: 21177701
Lou et al (2017) E2 Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1. Int J Biol Sci 13 434 PMID: 28529452
El-Mayet et al (2019) Synergistic Activation of Bovine Herpesvirus 1 Productive Infection and Viral Regulatory Promoters by the Progesterone Receptor and Krüppel-Like Transcription Factor 15. J Virol 93 PMID: 30305353
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