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Submit ReviewProglumide sodium salt
说明： Non-selective CCK antagonist; orally active
化学名： 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
纯度： ≥98% (HPLC)
生物活性 for Proglumide sodium salt
Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.
技术数据 for Proglumide sodium salt
| 分子量 | 356.39 |
| 公式 | C18H25N2NaO4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 99247-33-3 |
| PubChem ID | 23677833 |
| InChI Key | UFMWGCINVOIJSO-UHFFFAOYSA-M |
| Smiles | [Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Proglumide sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 35.64 | 100 |
制备储备液 for Proglumide sodium salt
以下数据基于产品分子量 356.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.03 mL | 28.06 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for Proglumide sodium salt
参考文献 for Proglumide sodium salt
参考文献是支持产品生物活性的出版物。
Iwamoto et al (1984) In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 19 53 PMID: 6202584
Mauss et al (1994) Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 14 215 PMID: 8166452
Hahne et al (1981) Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 78 6304 PMID: 6171817
If you know of a relevant reference for Proglumide sodium salt, please let us know.
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关键词: Proglumide sodium salt, Proglumide sodium salt supplier, cholecystokinin, antagonists, non, selective, milid, orally, active, available, Non-selective, CCK, 1478, Tocris Bioscience
1 篇 Proglumide sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Proglumide sodium salt 的部分引用包括：
Shivapurkar et al (2023) Treatment with a Cholecystokinin Receptor Antagonist, Proglumide, Improves Efficacy of Immune Checkpoint Antibodies in Hepatocellular Carcinoma Int J Mol Sci 24 3625
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