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Submit ReviewPSC 833
说明： Inhibitor of P-gp-mediated MDR
别名： Valspodar
化学名： 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A
纯度： ≥98% (HPLC)
生物活性 for PSC 833
PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).
技术数据 for PSC 833
| 分子量 | 1214.62 |
| 公式 | C63H111N11O12 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 121584-18-7 |
| PubChem ID | 5281884 |
| InChI Key | YJDYDFNKCBANTM-QCWCSKBGSA-N |
| Smiles | C[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PSC 833
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 2 | 2 |
制备储备液 for PSC 833
以下数据基于产品分子量 1214.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.02 mM | 41.17 mL | 205.83 mL | 411.65 mL |
| 0.1 mM | 8.23 mL | 41.17 mL | 82.33 mL |
| 0.2 mM | 4.12 mL | 20.58 mL | 41.17 mL |
| 1 mM | 0.82 mL | 4.12 mL | 8.23 mL |
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产品说明书 for PSC 833
参考文献 for PSC 833
参考文献是支持产品生物活性的出版物。
Song et al (1998) Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo. J.Pharmacol.Exp.Ther. 287 963 PMID: 9864280
Goda et al (2007) Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J.Pharmacol.Exp.Ther. 320 81 PMID: 17050779
Shen et al (2008) Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J.Pharmacol.Exp.Ther. 324 95 PMID: 17947497
Shen et al (2009) Dynamic assessment of mitoxan. resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells. J.Pharmacol.Exp.Ther. 330 423 PMID: 19423841
If you know of a relevant reference for PSC 833, please let us know.
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关键词: PSC 833, PSC 833 supplier, PSC833, P-glycoprotein, inhibitors, inhibits, P-gp, cyclosporin, A, analog, analogue, ABCB1, Valspodar, Multidrug, Transporters, 4042, Tocris Bioscience
8 篇 PSC 833 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PSC 833 的部分引用包括：
Mark C et al (2021) Biomaterial screening of protein coatings and peptide additives: towards a simple synthetic mimic of a complex natural coating for a bio-artificial kidney. Biomater Sci 9 2209-2220 PMID: 33506836
Jos et al (2021) Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies. J Pharm Sci 110 1601-1614 PMID: 33545187
Elbaradie et al (2013) Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-OE involves differential regulation of plasma membrane associated estrogen receptors. Sci Rep 1833 1165 PMID: 23305904
Slosky et al (2013) Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Mol Pharmacol 84 774 PMID: 24019224
Kim and Bynoe (2016) A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest 126 1717 PMID: 27043281
Ong et al (2013) Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model. Antimicrob Agents Chemother 57 2535 PMID: 23507281
Michael et al (2022) Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease. Nat Genet 54 1690-1701 PMID: 36303074
Lipka et al (2012) Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells. PLoS One 7 e40853 PMID: 22815843
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PSC 833 的评论
平均评分: 5 (Based on 1 Review.)
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Highly stable.
By
Anonymous on 05/09/2020
分析类型： In Vitro
种属： Human
细胞系/组织： Human brain endothelial cell
50 mg/kg of PSC833 for 15 minutes
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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