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说明： Muscarinic receptor ligand; exhibits partial agonist and antagonist activity at different subtypes
化学名： (1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane oxalate
纯度： ≥98% (HPLC)
生物活性 for PTAC oxalate
PTAC oxalate is a muscarinic receptor ligand. Displays partial agonist activity at M2 and M4 receptors; exhibits antagonist effects at M1, M3 and M5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.
技术数据 for PTAC oxalate
| 分子量 | 359.46 |
| 公式 | C12H19N3S2.C2H2O4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 201939-40-4 |
| PubChem ID | 90488949 |
| InChI Key | LXXQOVMTAFXOKQ-IYPAPVHQSA-N |
| Smiles | CCCSC1=NSN=[C@]1[C@@H]2[C@H]3CCCN(C3)C2.O=C(C(O)=O)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PTAC oxalate
参考文献 for PTAC oxalate
参考文献是支持产品生物活性的出版物。
Raedler et al (2007) Towards a muscarinic hypothesis of schizophrenia. Mol.Psychiatry 12 232 PMID: 17146471
Shannon et al (1999) Muscarinic receptor agonists, like DA receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats. J.Pharmacol.Exp.Ther. 290 901 PMID: 10411607
Bymaster et al (1998) Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane. Eur.J.Pharmacol. 356 109 PMID: 9774240
关键词: PTAC oxalate, PTAC oxalate supplier, PTAC, antipsychotics, schizophrenia, selective, muscarinic, partial, agonists, antagonists, M1, M2, M3, M4, M5, Non-selective, Muscarinics, 4533, Tocris Bioscience
1 篇 PTAC oxalate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PTAC oxalate 的部分引用包括：
Wang et al (2017) The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg 124 1330 PMID: 28002166
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