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说明： Multidrug resistance protein (MRP) 4 inhibitor
化学名： N-[[[4-[[(Phenylmethyl)amino]sulfonyl]phenyl]amino]thioxomethyl]benzamide
纯度： ≥98% (HPLC)
生物活性 for PU 23
PU 23 is a multidrug resistance protein (MRP) 4 inhibitor. Sensitizes MRP4-overexpressing cells to the anticancer agent 6-Mercaptopurine (Cat. No. 4103; 6-MP) (IC50 values are 14.11 and 6.06 μM in the absence and presence of compound, respectively). Increases accumulation of 6-MP in MRP4-overexpressing cells.
技术数据 for PU 23
| 分子量 | 425.52 |
| 公式 | C21H19N3O3S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 817635-93-1 |
| PubChem ID | 4779049 |
| InChI Key | RYIRRFWVFHEXTH-UHFFFAOYSA-N |
| Smiles | O=C(NC(=S)NC1=CC=C(C=C1)[S](=O)(=O)NCC1=CC=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PU 23
参考文献 for PU 23
参考文献是支持产品生物活性的出版物。
Chen et al (2018) Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. PLoS One 13 e0205175 PMID: 30321196
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关键词: PU 23, PU 23 supplier, PU23, multidrug, resistance, protein, 4, MRP4, inhibitor, inhibits, ABCC4, Multidrug, Transporters, 6885, Tocris Bioscience
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