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(Z)-Pugnac

Cat. No. 3384 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： O-GlcNAcase and β-hexosaminidase inhibitor
化学名： O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (Z)-Pugnac

(Z)-Pugnac is an O-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.

技术数据 for (Z)-Pugnac

分子量 353.33
公式 C15H19N3O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 132489-69-1
PubChem ID 6074876
InChI Key PBLNJFVQMUMOJY-JXAWBTAJSA-N
Smiles OC(C1NC(C)=O)C(O)C(CO)O/C1=N\OC(NC2=CC=CC=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (Z)-Pugnac

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.33 100

制备储备液 for (Z)-Pugnac

以下数据基于产品分子量 353.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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产品说明书 for (Z)-Pugnac

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (Z)-Pugnac

参考文献是支持产品生物活性的出版物。

Dong and Hart (1994) Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol. J.Biol.Chem. 269 19321 PMID: 8034696

Macauley et al (2005) O-GlcNAcase uses substrate-assisted catalysis. J.Biol.Chem. 280 25313 PMID: 15795231

Perreira et al (2006) Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg.Med.Chem. 14 837 PMID: 16214344

If you know of a relevant reference for (Z)-Pugnac, please let us know.

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关键词: Pugnac, Pugnac supplier, O-GlcNAcase, β-hexosaminidase, beta-hexosaminidase, O-GlcNAc-β-N-acetylglucosaminidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, Hydrolases, Other, 3384, Tocris Bioscience

2 篇 (Z)-Pugnac 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (Z)-Pugnac 的部分引用包括：

Jo et al (2016) O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity. Oncotarget 7 57186 PMID: 27527864

Parween et al (2018) Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during in-Vitro Human Embryonic Cortical Neurogenesis. Front Cell Neurosci 11 415 PMID: 29311838

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