主页 / 药理学 / Enzymes / Reductases / Thioredoxin Reductases / Thioredoxin Reductase Inhibitors / PX 12

PX 12

Cat. No. 2954 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Thioredoxin-1 inhibitor
别名： IV-2
化学名： 2-[(1-Methylpropyl)dithio]-1H-imidazole
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PX 12

PX 12 is a thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

技术数据 for PX 12

分子量 188.31
公式 C7H12N2S2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 141400-58-0
PubChem ID 219104
InChI Key BPBPYQWMFCTCNG-UHFFFAOYSA-N
Smiles CC(CC)SSC1=NC=CN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PX 12

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.83 100

制备储备液 for PX 12

以下数据基于产品分子量 188.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.31 mL 26.55 mL 53.1 mL
5 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.53 mL 2.66 mL 5.31 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Thioredoxin Reductase Inhibitors

关键词: PX 12, PX 12 supplier, px12, thioredoxin-1, trx-1, inhibitors, inhibits, HIF-1alpha, HIF-1a, HIF-1α, IV-2, antiangiogenics, Antiangiogenics, Hypoxia, Inducible, Factors, Thioredoxin, Reductases, 2954, Tocris Bioscience

2 篇 PX 12 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PX 12 的部分引用包括：

Shin et al (2013) PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion. Oncol Lett 6 1804 PMID: 24260080

Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Cell Death Differ 31 31 PMID: 22463935

您是否知道使用了 Tocris PX 12 的优秀论文？ 请告知我们.

PX 12 的评论

目前没有该产品的评论。 Be the first to review PX 12 and earn rewards!

Have you used PX 12?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.