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Pyr 10

Cat. No. 6941 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective TRPC3 inhibitor
化学名： N-[4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pyr 10

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.

技术数据 for Pyr 10

分子量 449.37
公式 C18H13F6N3O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1315323-00-2
PubChem ID 53475435
InChI Key CVALMMCIOLXHDM-UHFFFAOYSA-N
Smiles CC1=CC=C(S(=O)(NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pyr 10

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 44.94 100

制备储备液 for Pyr 10

以下数据基于产品分子量 449.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.13 mL 22.25 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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参考文献 for Pyr 10

参考文献是支持产品生物活性的出版物。

Schleifer et al (2012) Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca2+ entry pathways. Br.J.Pharmacol. 167 1712 PMID: 22862290

Saliba et al (2019) Transient receptor potential canonical 3 and nuclear factor of activated T cells C3 signaling pathway critically regulates myocardial fibrosis. Antioxid.Redox.Signal. 30 1851 PMID: 30318928

If you know of a relevant reference for Pyr 10, please let us know.

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关键词: Pyr 10, Pyr 10 supplier, Pyr10, transient, receptor, potential, channel, C3, TRPC3, TRP, inhibitors, inhibits, store, operated, calcium, entry, ROCE, SOCE, TRPC, 6941, Tocris Bioscience

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Pyr 10 的评论

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Inhibits TRPC3 channel.
By Yuyang Sun on 05/30/2022
分析类型： In Vitro
种属： Human
细胞系/组织： PC12

Used pyr to inhibit TRPC3 channel in PC12 cells. It can inhibit OAG induced TRPC3 current.