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说明： Selective TRPC3 inhibitor
化学名： 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Pyr3
Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
技术数据 for Pyr3
| 分子量 | 456.63 |
| 公式 | C16H11Cl3F3N3O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1160514-60-2 |
| PubChem ID | 56964346 |
| InChI Key | RZHGONNSASQOAY-UHFFFAOYSA-N |
| Smiles | O=C(/C(Cl)=C(Cl)\Cl)NC(C=C2)=CC=C2N1N=CC(C(OCC)=O)=C1C(F)(F)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pyr3
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.66 | 100 |
制备储备液 for Pyr3
以下数据基于产品分子量 456.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.95 mL | 21.9 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for Pyr3
参考文献 for Pyr3
参考文献是支持产品生物活性的出版物。
Kiyonaka et al (2009) Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc.Natl.Acad.Sci. 106 5400
If you know of a relevant reference for Pyr3, please let us know.
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关键词: Pyr3, Pyr3 supplier, canonical, transient, receptor, potential, TRPC3, channels, inhibitors, inhibits, TRPC, 3751, Tocris Bioscience
5 篇 Pyr3 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pyr3 的部分引用包括：
Zhou et al (2014) Cerebellar modules operate at different frequencies. Elife 3 e02536 PMID: 24843004
Y S et al (2020) Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle. FASEB J 34 12991-13004 PMID: 32777143
Szteyn et al (2015) Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. Am J Physiol Regul Integr Comp Physiol 7 PMID: 25873305
Senadheera et al (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. ACS Chem Neurosci 305 R917 PMID: 23948776
Lee et al (2013) TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons. J Neurosci 33 1157 PMID: 23325252
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Pyr3 的评论
平均评分: 5 (Based on 1 Review.)
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Pyr3, a selective TRPC3 channel blocker in mesangial cell.
By
Hitesh Soni on 01/04/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Mesangial Cell
For in vitro study to block the TRP ion channel and elucidate the mechanism of proliferation of mesangial cells under normal and high glucose conditions and to understand the role of TRP ion channels in diabetic nephropathy.
