Q94 hydrochloride

Name: Q94 hydrochloride
Brand: Tocris Bioscience
SKU: 4755

Cat. No. 4755 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4755 has been discontinued.

View all Protease-Activated Receptors products.

说明： Negative allosteric modulator at PAR₁ receptor

化学名： 1-[(4-Chlorophenyl)methyl]-2-(phenylmethyl)-1H-benzimidazole hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Q94 hydrochloride

PAR₁ negative allosteric modulator (IC₅₀ = 916 nM); inhibits PAR₁-Gα_q interaction. Selective for PAR₁ over PAR₂. Blocks thrombin-induced intracellular calcium mobilization (IC₅₀ = 10.3 nM), CCL2 expression, ERK1/2 and MLC phosphorylation, and IP₃ production in cells.

技术数据 for Q94 hydrochloride

分子量	369.29
公式	C₂₁H₁₇ClN₂.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1052076-77-3
PubChem ID	16258217
InChI Key	WXIWQTVPWYFEHP-UHFFFAOYSA-N
Smiles	ClC(C=C4)=CC=C4CN2C1=CC=CC=C1N=C2CC3=CC=CC=C3.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Q94 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Q94 hydrochloride

参考文献是支持产品生物活性的出版物。

Deng et al (2008) Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR₁ to Gα_q and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol.Biol.Cell 19 2520 PMID: 18353977

Asteriti et al (2012) Modulation of PAR₁ signalling by benzimidazole compounds. Br.J.Pharmacol. 167 80 PMID: 22519452

Scotton et al (2009) Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J.Clin.Invest. 119 2550 PMID: 19652365

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篇 Q94 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Q94 hydrochloride 的引用文献。