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Quinidine

Cat. No. 4108 5 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Blocks sodium and potassium channels
化学名： (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
说明书
引用文献 (5)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Quinidine

Quinidine is a class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

技术数据 for Quinidine

分子量 324.42
公式 C20H24N2O2
储存 Store at -20°C
CAS Number 56-54-2
PubChem ID 3036746
InChI Key LOUPRKONTZGTKE-LHFMAAMQSA-N
Smiles O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Quinidine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.44 100
ethanol 8.11 25

制备储备液 for Quinidine

以下数据基于产品分子量 324.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Quinidine

参考文献是支持产品生物活性的出版物。

Caballero et al (2003) Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 138 1475 PMID: 12721103

Borggrefe et al (2005) Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 38 75 PMID: 16226079

Wu et al (2008) Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine Heart Rhythm. 5 1726 PMID: 19084812

If you know of a relevant reference for Quinidine, please let us know.

按标靶查看相关产品

关键词: Quinidine, Quinidine supplier, sodium, Na+, potassium, K+, channel, blockers, IKr, IKs, IK1, IK-ATP, Ito, INa, antiarrhythmic, class, 1A, torsade, de, pointes, prolongs, qt, interval, Other, Channel, Modulators, 4108, Tocris Bioscience

5 篇 Quinidine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Quinidine 的部分引用包括：

He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680

Jean-Didier et al (2017) GABAB receptors in neocortical and hippocampal pyramidal neurons are coupled to different potassium channels. Eur J Neurosci 46 2859-2866 PMID: 29131436

Kim et al (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 126 4088 PMID: 27669461

Richard et al (2013) Electrophysiological characterization and computational models of HVC neurons in the zebra finch. J Neurophysiol 110 1227-45 PMID: 23719205

Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734

您是否知道使用了 Tocris Quinidine 的优秀论文？ 请告知我们.

Quinidine 的评论

平均评分: 5 (基于 2 条评论。)

5 星
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4 星
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3 星
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2 星
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Also a non-competitive alpha-1 adrenoceptor antagonist.
By Alex Voisey on 12/15/2020
分析类型： In Vitro
种属： Rat

Excellent for blocking organic cation transport at 50 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.

review image
Product was used on voltage gated potassium channels Kv11.1 and Kv7.1.
By Anonymous on 12/21/2018
种属： Human

Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.

review image