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Submit ReviewR 1485 dihydrochloride
说明： Selective and high affinity 5-HT6 antagonist
化学名： 4-[(2-Fluorophenyl)sulfonyl]-3,4-dihydro-8-(1-piperazinyl)-2H-1,4-benzoxazine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for R 1485 dihydrochloride
R 1485 dihydrochloride is a selective and high affinity 5-HT6 antagonist (pKi = 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant.
技术数据 for R 1485 dihydrochloride
| 分子量 | 450.35 |
| 公式 | C18H20FN3O3S.2HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 90488993 |
| InChI Key | SNXURKRGPYXWRN-UHFFFAOYSA-N |
| Smiles | FC(C=CC=C4)=C4S(N2CCOC1=C(N3CCNCC3)C=CC=C12)(=O)=O.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for R 1485 dihydrochloride
参考文献 for R 1485 dihydrochloride
参考文献是支持产品生物活性的出版物。
Zhao et al (2007) 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists. Bioorg.Med.Chem.Lett. 17 3504 PMID: 17485206
Liu et al (2009) 5-HT6 antagonists as potential treatment for cognitive dysfunction. Drug Des.Rev. 70 145
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关键词: R 1485 dihydrochloride, R 1485 dihydrochloride supplier, R1485, dihydrochloride, selective, high, affinity, 5HT6, antagonists, 5-HT6, Receptors, 4964, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.