(R)-(-)-α-Methylhistamine dihydrobromide

Cat. No. 0569 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent, standard H₃ agonist

化学名： (R)-(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide

纯度： ≥98% (HPLC)

引用文献 (4)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性

(R)-(-)-α-Methylhistamine dihydrobromide is a very potent, high affinity H₃ agonist (K_D = 50.3 nM) that displays > 200-fold selectivity over H₄ receptors. Inhibits H₃-mediated histamine synthesis and release in the CNS and stimulates H₄-mediated eosinophil shape change (EC₅₀ = 66 nM).

S-enantiomer also available.

技术数据

分子量	287
公式	C₆H₁₁N₃.2HBr
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	868698-49-1
PubChem ID	45037031
InChI Key	RWHNAAABSGVRDT-ZJIMSODOSA-N
Smiles	N[C@H](C)CC1=CNC=N1.Br.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	28.7	100

制备储备液

以下数据基于产品分子量 287。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.42 mL	34.84 mL
5 mM	0.7 mL	3.48 mL	6.97 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Buckland et al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H₄ receptor. Br.J.Pharmacol. 140 1117 PMID: 14530216

Hew et al (1990) Characterization of histamine-H₃ receptors in guinea pig ileum with H₃-selective ligands. Br.J.Pharmacol. 101 621 PMID: 1963802

Oishi et al (1989) Effects of histamine H₃-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine modulation in the mouse and rat brain. J.Neurochem. 52 1388 PMID: 2540269

Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H₃-receptor. Agents Actions 30 13 PMID: 1695431

Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9

If you know of a relevant reference for (R)-(-)-α-Methylhistamine dihydrobromide, please let us know.

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关键词: (R)-(-)-alpha-Methylhistamine dihydrobromide, (R)-(-)-alpha-Methylhistamine dihydrobromide supplier, Potent, H3, agonists, Receptors, Histamine, histaminergic, (R)-(-)-alpha-Methylhistamine, dihydrobromide, 0569, Tocris Bioscience

4 篇 (R)-(-)-α-Methylhistamine dihydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-(-)-α-Methylhistamine dihydrobromide 的部分引用包括：

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. FASEB J 152 891 PMID: 17891168

Rapanelli et al (2016) The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem. 291 21042 PMID: 27510032

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477

Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. J Clin Invest 28 771 PMID: 24192459

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