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(R)-CE3F4

Cat. No. 5969 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Epac inhibitor; R-enantiomer of CE3F4 (Cat. No. 4793)
化学名： (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (R)-CE3F4

(R)-CE3F4 is an Epac inhibitor (IC50 values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).

许可信息

Sold for research use only under license from Inserm, Université Toulouse III - Paul Sabatier, Université Paris-Sud and Université d′Orléans.

技术数据 for (R)-CE3F4

分子量 351.01
公式 C11H10Br2FNO
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1593478-56-8
PubChem ID 73669655
InChI Key ZZLQPWXVZCPUGC-ZCFIWIBFSA-N
Smiles BrC1=C(F)C(Br)=C(CC[C@@H](C)N2C=O)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-CE3F4

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.1 100
ethanol 17.55 50

制备储备液 for (R)-CE3F4

以下数据基于产品分子量 351.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.24 mL 28.49 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for (R)-CE3F4

参考文献是支持产品生物活性的出版物。

Courilleau et al (2013) The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem.Biophys.Res.Commun. 440 443 PMID: 24099776

Boulton et al (2018) Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist. J.Am.Chem.Soc. 140 9624 PMID: 30016089

If you know of a relevant reference for (R)-CE3F4, please let us know.

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关键词: (R)-CE3F4, (R)-CE3F4 supplier, Epac, antagonists, antagonism, R-enantiomer, cAMP, Rap1, guanine-nucleotide, exhange, factor, GEF, RAPGEF3, EPAC, 5969, Tocris Bioscience

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