(R,R)-THC

Cat. No. 1990 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent subtype-selective ligand; ERα agonist/ERβ antagonist

化学名： (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol

纯度： ≥98% (HPLC)

引用文献 (8)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (R,R)-THC

(R,R)-THC is a non-steroidal, selective estrogen receptor ligand. (R,R)-THC is an agonist at ERα receptor (K_i = 9.0 nM) and antagonist at ERβ receptor (K_i = 3.6 nM).

技术数据 for (R,R)-THC

分子量	320.42
公式	C₂₂H₂₄O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	138090-06-9
PubChem ID	446849
InChI Key	MASYAWHPJCQLSW-ZIAGYGMSSA-N
Smiles	OC3=CC=C(C(C[C@H]4CC)=C3)C2=C4C1=CC=C(O)C=C1C[C@H]2CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R,R)-THC

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	32.04	100
	ethanol	32.04	100

制备储备液 for (R,R)-THC

以下数据基于产品分子量 320.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.6 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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产品说明书 for (R,R)-THC

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (R,R)-THC

参考文献是支持产品生物活性的出版物。

Sun et al (1999) Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β. Endocrinology 140 800 PMID: 9927308

Kraichely et al (2000) Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141 3534 PMID: 11014206

Meyers et al (1999) Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J.Med.Chem. 42 2456 PMID: 10395487

If you know of a relevant reference for (R,R)-THC, please let us know.

按标靶查看相关产品

Estrogen and Related Receptors

关键词: (R,R)-THC, (R,R)-THC supplier, Potent, subtype, selective, ligands, Erα, Eralpha, agonists, ERβ, ERbeta, antagonists, ER, ERR, Estrogen, Receptors, and, Related, 1990, Tocris Bioscience

8 篇 (R,R)-THC 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R,R)-THC 的部分引用包括：

Wang et al (2015) Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α. Drug Des Devel Ther 9 3755 PMID: 26229438

Guo et al (2011) Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. J Biol Chem 286 27882 PMID: 21652696

Vona et al (2019) Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling? Cell Physiol Biochem 53 186 PMID: 31278696

Li et al (2013) Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. Br J Pharmacol 170 489 PMID: 23347118

Simpkins et al (2012) Src Inhibition with saracatinib reverses fulves. resistance in ER-positive ovarian cancer models in vitro and in vivo. Clin Cancer Res 18 5911 PMID: 22896656

Xing et al (2012) Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β. PLoS One 7 e36890 PMID: 22723832

Nicholson et al (2015) Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia. PLoS One 193 722 PMID: 25167991

Kola et al The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One 3 e1797 PMID: 18335063

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Pathways for (R,R)-THC

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.