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View all Adrenergic α<sub>1</sub> Receptors products.Rec 15/2615 dihydrochloride is a selective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).
分子量 | 568.49 |
公式 | C26H33N5O5.2HCl |
储存 | Desiccate at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 1782573-48-1 |
PubChem ID | 56972225 |
InChI Key | XZGSTPYGKYGQLD-UHFFFAOYSA-N |
Smiles | NC2=NC(N3CCN(C(COC4=C(OC)C=CC=C4C(C)C)=O)CC3)=NC1=CC(OC)=C(OC)C=C12.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
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参考文献是支持产品生物活性的出版物。
Testa et al (1997) Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J.Pharmacol.Exp.Ther. 281 1284 PMID: 9190864
Bremner et al (2000) Ligand design for α1 adrenoceptor subtype selective antagonist. Bioorg.Med.Chem. 8 201 PMID: 10968279
Morston et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072
关键词: Rec 15/2615 dihydrochloride, Rec 15/2615 dihydrochloride supplier, Selective, α1B-adrenoceptor, alpha1B-adrenoceptor, a1b-adrenoceptor, antagonists, α1b-adrenergic, alpha1b-adrenergic, a1b-adrenergic, Receptors, Rec15/2615, dihydrochloride, Adrenergic, Alpha-1, 3284, Tocris Bioscience
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.