Rec 15/2615 dihydrochloride

Discontinued Product

3284 has been discontinued.

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说明: Selective α1B antagonist
化学名: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[2-methoxy-6-(1-methylethyl)phenoxy]acetyl]piperazine dihydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献
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生物活性 for Rec 15/2615 dihydrochloride

Rec 15/2615 dihydrochloride is a selective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).

技术数据 for Rec 15/2615 dihydrochloride

分子量 568.49
公式 C26H33N5O5.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1782573-48-1
PubChem ID 56972225
InChI Key XZGSTPYGKYGQLD-UHFFFAOYSA-N
Smiles NC2=NC(N3CCN(C(COC4=C(OC)C=CC=C4C(C)C)=O)CC3)=NC1=CC(OC)=C(OC)C=C12.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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产品说明书 for Rec 15/2615 dihydrochloride

参考文献 for Rec 15/2615 dihydrochloride

参考文献是支持产品生物活性的出版物。

Testa et al (1997) Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J.Pharmacol.Exp.Ther. 281 1284 PMID: 9190864

Bremner et al (2000) Ligand design for α1 adrenoceptor subtype selective antagonist. Bioorg.Med.Chem. 8 201 PMID: 10968279

Morston et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072

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关键词: Rec 15/2615 dihydrochloride, Rec 15/2615 dihydrochloride supplier, Selective, α1B-adrenoceptor, alpha1B-adrenoceptor, a1b-adrenoceptor, antagonists, α1b-adrenergic, alpha1b-adrenergic, a1b-adrenergic, Receptors, Rec15/2615, dihydrochloride, Adrenergic, Alpha-1, 3284, Tocris Bioscience

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