主页 / 药理学 / GPCRs / 7-TM Receptors / Chemokine Receptors / Chemokine CXC Receptors / Chemokine CXC Receptor Antagonists / Reparixin L-lysine salt

Reparixin L-lysine salt

Cat. No. 6957 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6957 has been discontinued.

View all Chemokine CXC Receptors products.
说明： Potent CXCR1 and CXCR2 allosteric antagonist
别名： Repertaxin L-lysine salt
化学名： (αR)-α-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide L-Lysine salt
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Reparixin L-lysine salt

Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist (IC50 = 1 nM for inhibition of CXCL8-induced human polymorphonuclear cell migration). Also inhibits migration of rodent neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. Inhibits vascular permeability and neutrophil recruitment in in vivo models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models.

技术数据 for Reparixin L-lysine salt

分子量 429.58
公式 C14H21NO3S.C6H14N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 266359-93-7
PubChem ID 9932389
InChI Key JEJFWWFZAQBZMJ-GVKMLHTLSA-N
Smiles NCCCC[C@H](N)C(O)=O.CC(C)CC1=CC=C(C=C1)[C@@H](C)C(=O)N[S](C)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Reparixin L-lysine salt

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Reparixin L-lysine salt

参考文献是支持产品生物活性的出版物。

Bertini et al (2004) Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc.Natl.Acad.Sci.U.S.A. 101 11791 PMID: 15282370

Souza et al (2004) Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. Br.J.Pharmacol. 143 132 PMID: 15302676

Ginestier et al (2010) CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J.Clin.Invest. 120 485 PMID: 20051626

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Chemokine CXC Receptor Antagonists

关键词: Reparixin L-lysine salt, Reparixin L-lysine salt supplier, repertaxin, CXCR1, CXCR2, chemokine, receptor, antagonists, antagonism, allosteric, noncompetitive, IL-8, CXCL8, interleukin, 8, Repertaxin, L-lysine, salt, Chemokine, CXC, Receptors, Cancer, Stem, Cells, 6957, Tocris Bioscience

篇 Reparixin L-lysine salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Reparixin L-lysine salt 的引用文献。

Reparixin L-lysine salt 的评论

目前没有该产品的评论。 Be the first to review Reparixin L-lysine salt and earn rewards!

Have you used Reparixin L-lysine salt?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.