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Submit ReviewRGDS peptide
说明： Integrin binding sequence; inhibits integrin receptor function
纯度： ≥95% (HPLC)
生物活性 for RGDS peptide
RGDS peptide is an integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
技术数据 for RGDS peptide
| 分子量 | 433.42 |
| 公式 | C15H27N7O8 |
| 序列 | RGDS |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 91037-65-9 |
| PubChem ID | 107775 |
| InChI Key | NNRFRJQMBSBXGO-CIUDSAMLSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RGDS peptide
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for RGDS peptide
参考文献 for RGDS peptide
参考文献是支持产品生物活性的出版物。
Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733 PMID: 15522882
Moon et al (2009) Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 10 18 PMID: 19272161
Droppelmann et al (2009) Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 284 13551 PMID: 19276073
If you know of a relevant reference for RGDS peptide, please let us know.
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关键词: RGDS peptide, RGDS peptide supplier, Integrin, binding, sequence, inhibits, inhibitors, Receptors, Adhesion, Molecules, Cell, Integrins, 3498, Tocris Bioscience
14 篇 RGDS peptide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RGDS peptide 的部分引用包括：
Marko et al (2022) The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis. Front Oncol 12 777634 PMID: 35211397
Anne et al (2022) Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina. Dev Cell 57 2321-2333.e9 PMID: 36220082
Tao et al (2022) Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy. Adv Sci (Weinh) 9 e2104469 PMID: 35166070
Pradyut K et al (2022) Pancreatic Stellate Cells Prolong Ex Vivo Islet Viability and Function and Improve Engraftment. Stem Cells Transl Med 11 630-643 PMID: 35438788
Conant (2017) Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation 14 56 PMID: 28302163
Paul C et al (2020) β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells. Sci Rep 10 12644 PMID: 32724089
Bian et al (2017) Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res 5 17008 PMID: 28392965
Yan et al (2016) Dopamine increases NMDA-stimulated calcium flux in striatopallidal neurons through a matrix metalloproteinase-dependent mechanism. Eur J Neurosci 43 194-203 PMID: 26660285
Baghdadi (2018) Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature 557 714 PMID: 29795344
Sean P et al (2018) Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell 34 659-673.e6 PMID: 30270124
Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828
Kang et al (2012) Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice. J Neurosci 32 9277 PMID: 22764235
Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114
Ahmed et al (2015) Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells. J Radiat Res 2 85 PMID: 25692127
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Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments.
By
Anonymous on 03/24/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： rat astroglioma C6 cells
Co-incubated with RGDS 10 µg/ml
Mitochondrial bioenergetics measurements by reagent screen.
By
Anonymous on 03/15/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： mouse brain endothelioma cell line
100 μg/ml
该领域的文献
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