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Rhein

Cat. No. 6867 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6867 has been discontinued.

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说明： FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3
化学名： 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Rhein

Rhein is a FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo.

技术数据 for Rhein

分子量 284.22
公式 C15H8O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 478-43-3
PubChem ID 10168
InChI Key FCDLCPWAQCPTKC-UHFFFAOYSA-N
Smiles OC(=O)C1=CC2=C(C(O)=C1)C(=O)C1=C(O)C=CC=C1C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Rhein

参考文献是支持产品生物活性的出版物。

Chen et al (2012) Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor. J.Am.Chem.Soc. 134 17963 PMID: 23045983

Svensen and Jaffrey et al (2016) Fluorescent RNA aptamers as a tool to study RNA-modifying enzymes. Cell.Chem.Biol. 23 415 PMID: 26877022

Li et al (2016) Rhein inhibits AlkB repair enzymes and sensitizes cells to methylated DNA damage. J.Biol.Chem. 291 11083 PMID: 27015802

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关键词: Rhein, Rhein supplier, mRNA, N6-methyladenine, demethylase, FTO, ALKBH9, Fat, mass, and, obesity-associated, protein, α, alpha-ketoglutarate-dependent, dioxygenase, inhibitors, inhibits, competitive, anti-inflammatory, anticancer, chemosensitizers, chemosensitizing, ALKBH2, ALKBH3, DNA, damage, r, Other, Oxygenases/Oxidases, 6867, Tocris Bioscience

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