Rhosin hydrochloride

Cat. No. 5003 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Rho inhibitor

化学名： D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Rhosin hydrochloride

Rhosin hydrochloride is a Rho GTPase inhibitor (K_d = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.

技术数据 for Rhosin hydrochloride

分子量	394.86
公式	C₂₀H₁₈N₆O.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1281870-42-5
PubChem ID	44662615
InChI Key	SFRGBDFQSLZYLF-GRYLRVQNSA-N
Smiles	N[C@@H](C(N/N=C/C3=CC=C(N=CC=N4)C4=C3)=O)CC2=CNC1=CC=CC=C12.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rhosin hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	7.9	20 温和加热
	DMSO	39.49	100

制备储备液 for Rhosin hydrochloride

以下数据基于产品分子量 394.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.66 mL	25.33 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for Rhosin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Rhosin hydrochloride

参考文献是支持产品生物活性的出版物。

Shang et al (2013) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A. 110 3155 PMID: 23382194

Shang et al (2012) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol. 19 699 PMID: 22726684

If you know of a relevant reference for Rhosin hydrochloride, please let us know.

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关键词: Rhosin hydrochloride, Rhosin hydrochloride supplier, Rho, GTPases, inhibitors, inhibits, guanine, nucleotide, exchange, factors, GEF, 5003, Tocris Bioscience