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Submit ReviewRI-STAD 2
Discontinued Product
6567 has been discontinued.
说明： AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
生物活性 for RI-STAD 2
RI-STAD 2 is an AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.
技术数据 for RI-STAD 2
| 分子量 | 2401.75 |
| 公式 | C109H181N25O35 |
| 序列 |
LXQYAXQLADQIIKEATEK (Modifications: Leu-1 = NH2-PEG3-CH2-CO-Leu, X = (S)-2-(4-pentenyl)alanine, X-2 and X-6 stapled together with a double bond) |
| 储存 | Store at -20°C |
| Smiles | O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@](CCC/C=C/CCC[C@](NC([C@H](CC(C)C)NC(COCCOCCOCCN)=O)=O)(C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H]2C)=O)=O)=O)C)(NC2=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RI-STAD 2
参考文献 for RI-STAD 2
参考文献是支持产品生物活性的出版物。
Wang et al (2015) PKA-type I selective constrained peptide disruptors of AKAP complexes. ACS Chem.Biol. 10 1502 PMID: 25765284
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关键词: RI-STAD 2, RI-STAD 2 supplier, RI-STAD2, stapled, peptide, selective, AKAP, disruptors, disrupts, a-kinase, anchoring, proteins, RI, PKA, protein, kinase, A, A-kinase-anchoring, protiens, Stapled, Peptides, 6567, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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