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Ribociclib

Cat. No. 7050 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Dual cdk4/cdk6 inhibitor; orally bioavailable
别名： LEE-011
化学名： 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ribociclib

Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo. Orally bioavailable.

技术数据 for Ribociclib

分子量 434.54
公式 C23H30N8O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1211441-98-3
PubChem ID 44631912
InChI Key RHXHGRAEPCAFML-UHFFFAOYSA-N
Smiles CN(C(C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ribociclib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.35 10

制备储备液 for Ribociclib

以下数据基于产品分子量 434.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 23.01 mL 115.06 mL 230.13 mL
0.5 mM 4.6 mL 23.01 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.01 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

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参考文献 for Ribociclib

参考文献是支持产品生物活性的出版物。

Rader et al (2013) Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 19 6173 PMID: 24045179

If you know of a relevant reference for Ribociclib, please let us know.

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关键词: Ribociclib, Ribociclib supplier, Dual, cdk4, cdk6, inhibitors, inhibits, orally, bioavailable, LEE-011, Cyclin-dependent, Kinase, CDK4, Subfamily, 7050, Tocris Bioscience

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