Rilmenidine hemifumarate

Cat. No. 0790 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： I₁ ligand. Also α₂ agonist

化学名： 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Rilmenidine hemifumarate

Rilmenidine hemifumarate is an I₁-imidazoline binding site selective ligand and α₂-adrenoceptor agonist. Possesses greater I₁ vs α₂ selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

技术数据 for Rilmenidine hemifumarate

分子量	238.29
公式	C₁₀H₁₆N₂O.½C₄H₄O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	207572-68-7
PubChem ID	45073450
InChI Key	LZFATBMLSYHRTC-WXXKFALUSA-N
Smiles	OC(=O)\C=C\C(O)=O.C1CC1C(NC1=NCCO1)C1CC1.C1CC1C(NC1=NCCO1)C1CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rilmenidine hemifumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	5.96	25

制备储备液 for Rilmenidine hemifumarate

以下数据基于产品分子量 238.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	16.79 mL	83.93 mL	167.86 mL
1.25 mM	3.36 mL	16.79 mL	33.57 mL
2.5 mM	1.68 mL	8.39 mL	16.79 mL
12.5 mM	0.34 mL	1.68 mL	3.36 mL

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产品说明书 for Rilmenidine hemifumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Rilmenidine hemifumarate

参考文献是支持产品生物活性的出版物。

Bricca et al (1994) Human brain imidazoline receptors: Further characterisation with [³H] clon. Eur.J.Pharmacol. 266 25 PMID: 8137880

Bricca et al (1989) Rilmenidine selectivity for imidazoline receptors in human brain. Eur.J.Pharmacol. 163 373 PMID: 2566507

Mammoto et al (1996) Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br.J.Pharmacol. 117 1744 PMID: 8732285

Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TiPS 13 369 PMID: 1413085

Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295 PMID: 18391949

If you know of a relevant reference for Rilmenidine hemifumarate, please let us know.

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关键词: Rilmenidine hemifumarate, Rilmenidine hemifumarate supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, I1, ligand, Receptors, Imidazoline, Adrenergic, Alpha-2, Autophagy, 0790, Tocris Bioscience

1 篇 Rilmenidine hemifumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Rilmenidine hemifumarate 的部分引用包括：

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010

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