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Submit ReviewRiluzole hydrochloride
说明： GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
化学名： 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Riluzole hydrochloride
Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.
技术数据 for Riluzole hydrochloride
| 分子量 | 270.66 |
| 公式 | C8H5F3N2OS.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 850608-87-6 |
| PubChem ID | 6419992 |
| InChI Key | QEAOELIJQRYJJS-UHFFFAOYSA-N |
| Smiles | Cl.NC1=NC2=CC=C(OC(F)(F)F)C=C2S1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Riluzole hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 27.07 | 100 | |
| water | 2.71 | 10 温和加热 |
制备储备液 for Riluzole hydrochloride
以下数据基于产品分子量 270.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.47 mL | 36.95 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.39 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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产品说明书 for Riluzole hydrochloride
参考文献 for Riluzole hydrochloride
参考文献是支持产品生物活性的出版物。
Fumagalli et al (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol. 578 171 PMID: 18036519
Song et al (1997) Differential action of Riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 282 707 PMID: 9262334
Taylor and Meldrum (1995) Na+ channels as targets for neuroprotective drugs. TiPS 16 309 PMID: 7482996
Umeniya and Berger (1995) Inhibition by Riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 116 3227 PMID: 8719800
Richter et al (2014) Riluzole activates TRPC5 channels independently of PLC activity. Br.J.Pharmacol. 171 158 PMID: 24117252
If you know of a relevant reference for Riluzole hydrochloride, please let us know.
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关键词: Riluzole hydrochloride, Riluzole hydrochloride supplier, Glutamate, release, inhibitors, inhibits, GABA, uptake, Na+, channel, blockers, glutamate, mGlur, Receptors, Metabotropic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, iGlu, Ionotropic, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, neuroprotective, TRPC5, canon, Miscellaneous, Voltage-gated, TRPC, 0768, Tocris Bioscience
15 篇 Riluzole hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Riluzole hydrochloride 的部分引用包括：
Park et al (2013) Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons. J Neurophysiol 109 1378 PMID: 23236005
Morgado-Valle et al (2010) Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse. J Neurosci 30 3634 PMID: 20219997
Le et al (2010) The glutamate release inhibitor R.zole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol 130 2240 PMID: 20505744
Carbone et al (2012) R.zole elevates GLT-1 activity and levels in striatal astrocytes. BMC Neurosci 60 42613 PMID: 22080156
Carbone et al (2012) R.zole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. Cells 13 38 PMID: 22480308
Zhang et al (2018) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation. Neuron 98 918 PMID: 29754751
Shin et al (2018) Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis 7 86 PMID: 30425240
Sexton et al (2018) Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer. Sci Rep 8 16008 PMID: 30375476
Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun 6 6626 PMID: 25806427
Viemari et al (2013) β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Neurochem Int 7 179 PMID: 24273495
Sperling et al (2017) Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells. Oncotarget 8 96697 PMID: 29228563
Veettil et al (2014) Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog 10 e1004389 PMID: 25299066
Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat.Commun. 6 6626 PMID: 25806427
Dolfi et al (2017) R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget 8 44639 PMID: 28591718
Rosenberg et al (2015) Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Front Neural Circuits 8 42614 PMID: 25749171
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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