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RIPGBM

Cat. No. 6892 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
化学名： N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RIPGBM

RIPGBM is a RIPK2 modulator, pro-drug of cRIPGM. cRIPGM binds RIPK2 (apparent Kd = 2.3 μM). Selectively induces apoptosis in glioblastoma multiforme cancer stem cell lines (EC50 is <500 nM). Five-fold selective for CSCs compared with control cell types. Reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex. Inhibits tumor formation and growth in vivo. Orally bioavailable and brain penetrant.

技术数据 for RIPGBM

分子量 428.46
公式 C26H21FN2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 355406-76-7
InChI Key COATXBHZYVUJQP-UHFFFAOYSA-N
Smiles CC(=O)N(CC1=CC=C(F)C=C1)C1=C(NCC2=CC=CC=C2)C(=O)C2=CC=CC=C2C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RIPGBM

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.28 10

制备储备液 for RIPGBM

以下数据基于产品分子量 428.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.7 mL 233.39 mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

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参考文献 for RIPGBM

参考文献是支持产品生物活性的出版物。

Lucki et al (2019) A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc.Natl.Acad.Sci.USA. 116 6435 PMID: 30846550

If you know of a relevant reference for RIPGBM, please let us know.

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关键词: RIPGBM, RIPGBM supplier, Pro-drug, cRIPGM, RIPK2, modulators, modulates, apoptosis, glioblastoma, multiforme, cancer, orally, bioavailable, and, brain, penetrant., RIP, Kinases, 6892, Tocris Bioscience

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