RIPK2 inhibitor 1

Cat. No. 6603 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent RIPK2 inhibitor

化学名： 3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RIPK2 inhibitor 1

RIPK2 inhibitor 1 is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC₅₀ of 5-10 nM). It inhibits NF-κB activity and decreases cancer cell proliferation by 70%. In vivo, RIPK2 inhibitor 1 inhibits intestinal and lung inflammation with low toxicity in rodent models.

技术数据 for RIPK2 inhibitor 1

分子量	410.48
公式	C₂₅H₂₂N₄O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1290490-78-6
PubChem ID	99506096
InChI Key	OIIYBZHRYXJCHR-UHFFFAOYSA-N
Smiles	CN1C=CN=C1C2=CC(NC(C3=CC(NC(C4=CC=CC=C4)=O)=C(C)C=C3)=O)=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RIPK2 inhibitor 1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	41.05	100

制备储备液 for RIPK2 inhibitor 1

以下数据基于产品分子量 410.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for RIPK2 inhibitor 1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RIPK2 inhibitor 1

参考文献是支持产品生物活性的出版物。

Salla et al (2018) Identification and characterization of novel receptor-interacting serine/threonine-protein kinase 2 inhibitors using structural similarity analysis. J.Pharmacol.Exp.Ther. 365 354 PMID: 29555876

If you know of a relevant reference for RIPK2 inhibitor 1, please let us know.

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