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说明： Farnesyl diphosphate (FPP) synthase inhibitor
化学名： P,P'-[1-Hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic acid sodium salt
纯度： ≥99% (HPLC)
生物活性 for Risedronate
Risedronate is an orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC50 = 100 nM). Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone resorption in vivo.
技术数据 for Risedronate
| 分子量 | 305.09 |
| 公式 | C7H10NNaO7P2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 115436-72-1 |
| PubChem ID | 68739 |
| InChI Key | DRFDPXKCEWYIAW-UHFFFAOYSA-M |
| Smiles | OC(P(O)(O)=O)(P([O-])(O)=O)CC1=CC=CN=C1.[Na+] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Risedronate
参考文献 for Risedronate
参考文献是支持产品生物活性的出版物。
Coxon et al (2006) Recent advances in understanding the mechanism of action of bisphosphonates. Curr.Opin.Pharmacol. 6 307 PMID: 16650801
Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic stragey to optimize skeletal tumor growth inhibition in vivo. Cancer Res. 68 8945 PMID: 18974139
Stresing et al (2007) Bisphosphonates in cancer therapy. Cancer Letts. 257 16 PMID: 17697748
Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603
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关键词: Risedronate, Risedronate supplier, Farnesyl, diphosphate, FPP, inhibitors, inhibits, Synthases, Synthetases, Other, Synthases/Synthetases, 3504, Tocris Bioscience
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