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Submit ReviewRJR 2403 oxalate
说明： Selective α4β2 nAChR agonist
别名： Metanicotine,TC-2403
化学名： (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
纯度： ≥99% (HPLC)
生物活性 for RJR 2403 oxalate
RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.
技术数据 for RJR 2403 oxalate
| 分子量 | 252.27 |
| 公式 | C10H14N2.C2H2O4 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 220662-95-3 |
| PubChem ID | 23298272 |
| InChI Key | WTIZFOAIQXMQHC-DPZBITMOSA-N |
| Smiles | O=C(O)C(O)=O.CNCC/C=C/C1=CC=CN=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RJR 2403 oxalate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25.23 | 100 |
制备储备液 for RJR 2403 oxalate
以下数据基于产品分子量 252.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.82 mL | 39.64 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.93 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
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产品说明书 for RJR 2403 oxalate
参考文献 for RJR 2403 oxalate
参考文献是支持产品生物活性的出版物。
Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413 PMID: 8968366
Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390 PMID: 10490929
Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422 PMID: 8968367
If you know of a relevant reference for RJR 2403 oxalate, please let us know.
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关键词: RJR 2403 oxalate, RJR 2403 oxalate supplier, α4β2, selective, nicotinic, agonists, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, RJR2403, oxalate, Metanicotine, TC-2403, (a4b2), 1053, Tocris Bioscience
6 篇 RJR 2403 oxalate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RJR 2403 oxalate 的部分引用包括：
Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Dev Neurobiol 8 e82719 PMID: 24349346
Zakharova et al (2011) Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory. Int J Alzheimers Dis 2010 954589 PMID: 21197444
Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328
Liu et al (2009) A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci 29 918 PMID: 19176801
Li et al (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett 462 20 PMID: 19573576
Scholze et al (2011) α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion. Cardiovasc Res 71 390 PMID: 21485013
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