RJR 2429 dihydrochloride

Name: RJR 2429 dihydrochloride
Brand: Tocris Bioscience
SKU: 1271

Cat. No. 1271 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1271 has been discontinued.

View all Nicotinic Receptors (Non-selective) products.

说明： nAChR agonist; displays selectivity for α4β2, α1βγδ and α3β4 subtypes

化学名： (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for RJR 2429 dihydrochloride

RJR 2429 dihydrochloride is a potent nAChR agonist that displays selectivity for α4β2 (K_i = 1 nM) and α1βγδ subtypes (EC₅₀ values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC₅₀ = 2 nM) and inhibits ion flux in thalamic neurons (IC₅₀ = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.

技术数据 for RJR 2429 dihydrochloride

分子量	261.19
公式	C₁₂H₁₆N₂.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1021418-53-0
PubChem ID	56972204
InChI Key	PIUNXHHZRIUBOV-UHFFFAOYSA-N
Smiles	C1(C2N3CCC(CC3)C2)=CC=CN=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RJR 2429 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RJR 2429 dihydrochloride

参考文献是支持产品生物活性的出版物。

Bencherif et al (1998) The heterocyclic substituted pyridine derivative (±)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 284 886 PMID: 9495846

Bhatti et al (2008) Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J.Org.Chem. 73 3497 PMID: 18363376

Yokotani et al (2002) Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from isolated rat adrenal gland. Eur.J.Pharmacol. 446 83 PMID: 12098588

按标靶查看相关产品

关键词: RJR 2429 dihydrochloride, RJR 2429 dihydrochloride supplier, Nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, RJR2429, dihydrochloride, (Non-selective), 1271, Tocris Bioscience

篇 RJR 2429 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 RJR 2429 dihydrochloride 的引用文献。