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RNB 61

Cat. No. 8835 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent and selective CB2R agonist
化学名： N-[(3E)-5-tert-Butyl-2-(cyclobutylmethyl)-1-methyl-1,2-dihydro-3H-pyrazol-3-ylidene]-2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzamide
纯度： ≥97% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RNB 61

RNB 61 is a highly potent and selective cannabinoid CB2 receptor (CB2R) agonist (Ki = 0.57 nM). RNB 61 shows >5000-fold selectivity for hCB2R over hCB1R. In vivo, RNB 61 inhibits the FSK-induced cAMP formation on mouse, rat, and dog CB2Rs (EC50 values ranging from 0.13 to 1.86 nM).

技术数据 for RNB 61

分子量 481.56
公式 C25H34F3N3O3
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1217403-51-4
PubChem ID 66642909
InChI Key SHUYRGCUYVGFJV-XHLNEMQHSA-N
Smiles O=C(C1=C(C=CC(C(F)(F)F)=C1)OCC(C)(O)C)/N=C2N(N(C(C(C)(C)C)=C/2)C)CC3CCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RNB 61

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.08 50
ethanol 48.16 100

制备储备液 for RNB 61

以下数据基于产品分子量 481.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.38 mL 20.77 mL
5 mM 0.42 mL 2.08 mL 4.15 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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参考文献 for RNB 61

参考文献是支持产品生物活性的出版物。

Chicca et al (2024) A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor- selective full agonist for in vivo studies. ACS Pharmacol.Transl.Sci. 7 2424 PMID: 39144568

If you know of a relevant reference for RNB 61, please let us know.

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关键词: RNB 61, RNB 61 supplier, RNB61, cannabinoid, CB2, agonists, receptors, potent, selective, agonism, orally, bioavailable, anti-inflammatory, in, vivo, Receptors, 8835, Tocris Bioscience

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