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Submit ReviewRo 0437626
说明： Selective P2X1 antagonist
化学名： N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for Ro 0437626
Ro 0437626 is a selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).
技术数据 for Ro 0437626
| 分子量 | 525.66 |
| 公式 | C27H35N5O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 134362-79-1 |
| PubChem ID | 11663667 |
| InChI Key | JHRSGCIIDRWHCD-UARRHKHWSA-N |
| Smiles | O[C@@H](C1CC1)[C@H](O)[C@H](CC2CCCCC2)NC([C@@H](CC3=CSC=N3)NC(C(N4)=NC5=C4C=CC=C5)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ro 0437626
参考文献 for Ro 0437626
参考文献是支持产品生物活性的出版物。
Jaime-Figueroa et al (2005) Discovery and synthesis of a novel and selective drug-like P2X1 antagonist. Bioorg.Med.Chem.Lett. 15 3292 PMID: 15927468
King et al (2004) Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br.J.Pharmacol. 142 519 PMID: 15148261
Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132 PMID: 16465177
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关键词: Ro 0437626, Ro 0437626 supplier, Selective, P2X1, antagonists, P2X, Receptors, Purinergic, purinoceptors, Ro0437626, 2188, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.