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Submit ReviewRo 15-4513
说明： Benzodiazepine partial inverse agonist
化学名： 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
纯度： ≥98% (HPLC)
生物活性 for Ro 15-4513
Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
技术数据 for Ro 15-4513
| 分子量 | 326.31 |
| 公式 | C15H14N6O3 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 91917-65-6 |
| PubChem ID | 5081 |
| InChI Key | CFSOJZTUTOQNIA-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(=C3)N=[N+]=[N-])N2C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ro 15-4513
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 1.63 | 5 | |
| DMSO | 3.26 | 10 |
制备储备液 for Ro 15-4513
以下数据基于产品分子量 326.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.65 mL | 153.23 mL | 306.46 mL |
| 0.5 mM | 6.13 mL | 30.65 mL | 61.29 mL |
| 1 mM | 3.06 mL | 15.32 mL | 30.65 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.13 mL |
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产品说明书 for Ro 15-4513
参考文献 for Ro 15-4513
参考文献是支持产品生物活性的出版物。
Suzdak et al (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 1243 PMID: 3022383
Wong and Skolnick (1992) High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690
Knoflach et al (1996) Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 50 1253 PMID: 8913357
If you know of a relevant reference for Ro 15-4513, please let us know.
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关键词: Ro 15-4513, Ro 15-4513 supplier, Benzodiazepine, partial, inverse, agonists, GABAA, Receptors, Ro15-4513, 1997, Tocris Bioscience
2 篇 Ro 15-4513 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ro 15-4513 的部分引用包括：
Tracy et al (2016) Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology 233 715 PMID: 26612620
Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Neurosci 64 145 PMID: 22732440
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